| Autor: |
Jian Hong, Leiming Xia, Zhenqi Huang, Xiaodong Yuan, Xinglin Liang, Jifei Dai, Zhonghui Wu, Li Liang, Min Ruan, Zhangbiao Long, Xin Cheng, Xiaowen Chen, Jing Ni, Jian Ge, Qingsheng Li, Qingshu Zeng, Ruixiang Xia, Yi Wang, Mingzhen Yang |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Oncology, Vol 12 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2234-943X |
| DOI: |
10.3389/fonc.2022.879471 |
| Popis: |
BackgroundT-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) expresses on leukemic stem and progenitor populations of non-M3 acute myeloid leukemia (AML) as well as T lymphocytes. TIM-3 is thought to be involved in the self-renewal of leukemic stem cells and the immune escape of AML cells, however its correlation with AML prognosis is still controversial and worthy of further investigation.Methodswe simultaneously assessed TIM-3 expression levels of leukemic blasts and T lymphocytes in the bone marrow of de novo AML patients using flow cytometry. The correlations of TIM-3 expression between leukemic blasts and T lymphocytes and the correlations of TIM-3 expression with various patient parameters were analyzed. In addition, the Cancer Genome Atlas (TCGA) data of AML patients were acquired and analyzed to verify the results.ResultsTIM-3 expression of CD34+ leukemic blasts (R2 = 0.95, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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