A Triple-challenge Mouse Model of Allergic Airway Disease, Primary Influenza Infection, and Secondary Bacterial Infection

Autor: Sean Roberts, Clare Williams, Sreeja Roy, Yoichi Furuya
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Bio-Protocol, Vol 10, Iss 8 (2020)
Druh dokumentu: article
ISSN: 2331-8325
DOI: 10.21769/BioProtoc.3583
Popis: Asthma is a global problem that affects millions of individuals. An increased risk of respiratory viral and bacterial infections is one of the complications of asthma. We recently reported that mice with ovalbumin-induced allergic airway disease (AAD) are protected against influenza-Streptococcus pneumoniae co-infection. Here, we describe in detail a protocol on how to induce AAD and influenza-S. pneumoniae co-infection in mice and to evaluate the specific roles of asthma on immunity to viral and bacterial pathogens in the hope of translating findings to benefit asthmatic individuals.
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