The clinical significance of circulating microRNA-21 in patients with IgA nephropathy
| Autor: | A Young Cho, Ju Hwan Oh, Kwang Young Lee, In O Sun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Kosin Medical Journal, Vol 37, Iss 3, Pp 242-248 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2005-9531 2586-7024 |
| DOI: | 10.7180/kmj.22.116 |
| Popis: | Background Urinary microRNA-21 (miR-21) has been reported to correlate with the histologic lesions of IgA nephropathy (IgAN). We investigated whether urinary or circulating miR-21 could serve as a biomarker for detecting the renal progression of IgAN. Methods Forty patients with biopsy-proven IgAN were enrolled in this study. Serum and urinary sediment miRs were extracted, and the expression of miR-21 was quantified by real-time quantitative polymerase chain reaction. Renal progression was defined as end-stage renal disease, a sustained doubling of serum creatinine, or a 50% decrease in estimated glomerular filtration rate (eGFR) from baseline. Results Six patients experienced renal progression during the follow-up period. The baseline eGFR was lower in the progression group (49±11 mL/min/1.73 m2 vs. 90±23 mL/min/1.73 m2, p |
| Databáze: | Directory of Open Access Journals |
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