Measuring herpes zoster disease burden in São Paulo, Brazil: a clinico-epidemiological single-center study

Autor: João Toniolo-Neto, Eliofotisti Psaradellis, Angela Karellis, Emmanouil Rampakakis, Talita Y. Rockett, John S. Sampalis, Kelly D. Johnson, Homero A. Monsanto, Camilo J. Acosta
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Clinics, Vol 73, Iss 0 (2018)
Druh dokumentu: article
ISSN: 1980-5322
DOI: 10.6061/clinics/2018/e243
Popis: OBJECTIVES: Herpes zoster is characterized by acute neuritis and post-herpetic neuralgia. Currently, data concerning the zoster-associated impact on quality of life and healthcare resource utilization in Brazil are scarce. This study measured the zoster-associated burden in a Brazilian population. METHODS: This was a prospective, observational, single-cohort study conducted in a primary hospital’s emergency room in São Paulo, Brazil. Patients enrolled at various timepoints during a zoster episode were followed over 180 days. The Zoster Brief Pain Inventory and the Initial Zoster Impact Questionnaire assessed zoster-associated pain. The EuroQoL assessed the impact of herpes zoster and/or zoster-associated pain on quality of life. Healthcare resource utilization was assessed by patient-reported questionnaires. RESULTS: One-hundred forty-six zoster patients were enrolled [mean (SD) age of 69.9 (10.9) years]. Mean (SD) worst pain scores decreased from 5.3 (3.5) at baseline to 1.9 (3.0) 180 days following rash onset. Mean (SD) EuroQoL scores significantly decreased from 0.9 (0.2) before rash appearance to 0.7 (0.2) after rash onset (p
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