The association of physical activity and cardiorespiratory fitness with β-cell dysfunction, insulin resistance, and diabetes among adults in north-western Tanzania: A cross-sectional study
| Autor: | Brenda Kitilya, Robert Peck, John Changalucha, Kidola Jeremiah, Bazil B. Kavishe, Henrik Friis, Suzanne Filteau, Rikke Krogh-Madsen, Soren Brage, Daniel Faurholt-Jepsen, Mette F. Olsen, George PrayGod |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Frontiers in Endocrinology, Vol 13 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1664-2392 37824341 |
| DOI: | 10.3389/fendo.2022.885988 |
| Popis: | IntroductionResearch on the associations of physical activity and cardiorespiratory fitness with β-cell dysfunction and insulin resistance among adults in Sub-Saharan Africa (SSA) is limited. We assessed the association of physical activity and cardiorespiratory fitness with β-cell function, insulin resistance and diabetes among people living with HIV (PLWH) ART-naïve and HIV-uninfected Tanzanian adults.MethodIn a cross-sectional study, we collected data on socio-demography, anthropometry, fat mass and fat free mass and C-reactive protein. Data on glucose and insulin collected during an oral glucose tolerance test were used to assess β-cell dysfunction (defined as insulinogenic index 1.9 (mU/L)/(mmol/L) and Matsuda index 0.05).ConclusionAmong Tanzanian adults PLWH and HIV-uninfected individuals, low physical activity was associated with β-cell dysfunction, insulin resistance and diabetes. Research is needed to assess if physical activity interventions can improve β-cell function and insulin sensitivity to reduce risk of diabetes and delay progression of diabetes in SSA. |
| Databáze: | Directory of Open Access Journals |
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