| Autor: |
Șerban Margit, Poenaru Dan, Cernat Laura, Savescu Delia, Pătrașcu Jenel, Schramm Wolfgang, Ursu Emilia, Mihailov Delia, Jinca Cristian, Ioniță Ioana, Arghirescu Smaranda |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Romanian Journal of Laboratory Medicine, Vol 25, Iss 2, Pp 135-143 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2284-5623 |
| DOI: |
10.1515/rrlm-2017-0011 |
| Popis: |
The development of FVIII/FIX inhibitor alloantibodies represents a severe complication requiring specific laboratory evaluation for establishing a life-saving therapy regimen. Our preliminary study aimed at elaborating a laboratory strategy for monitoring the effectiveness of Activated Prothrombin Complex Concentrate (APCC) and recombinant activated factor VII (rFVIIa) in haemophiliacs with inhibitors, by checking the reliability and clinical value of three complementary assays: clotting-time based coagulometry, thrombelastography (TEG) and thrombin generation assay (TGA). The investigations were performed on 7 patients with severe haemophilia A with high titer inhibitors treated for 12 episodes of severe bleedings, 5 of them for surgical interventions. After the administration of bypassing agents (BPAs) the clotting-time based assay brought changes only on prothrombin (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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