| Autor: |
Pascal Brandys, Xavier Montagutelli, Irena Merenkova, Güliz T. Barut, Volker Thiel, Nicholas J. Schork, Bettina Trüeb, Laurine Conquet, Aihua Deng, Aleksandar Antanasijevic, Hyun-Ku Lee, Martine Valière, Anoop Sindhu, Gita Singh, Jens Herold |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 13 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2022.912898 |
| Popis: |
Two years into the COVID-19 pandemic there is still a need for vaccines to effectively control the spread of novel SARS-CoV-2 variants and associated cases of severe disease. Here we report a messenger RNA vaccine directly encoding for a nanoparticle displaying 60 receptor binding domains (RBDs) of SARS-CoV-2 that acts as a highly effective antigen. A construct encoding the RBD of the Delta variant elicits robust neutralizing antibody response, and also provides protective immunity against the Delta variant in a widely used transgenic mouse model. We ultimately find that the proposed mRNA RBD nanoparticle-based vaccine provides a flexible platform for rapid development and will likely be of great value in combatting current and future SARS-CoV-2 variants of concern. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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