Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium

Autor: Young-Woong Kim, Greta Zara, HyunJun Kang, Sergio Branciamore, Denis O’Meally, Yuxin Feng, Chia-Yi Kuan, Yingjun Luo, Michael S. Nelson, Alex B. Brummer, Russell Rockne, Zhen Bouman Chen, Yi Zheng, Angelo A. Cardoso, Nadia Carlesso
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-34425-z
Popis: Here Kim et al. show that primary BMECs can be maintained ex vivo as distinct sinusoidal- and arterial-like populations and that the presence of macrophages is critical to preserve their native transcriptomic profiles and functional heterogeneity.
Databáze: Directory of Open Access Journals