Isolation of a Melanoblast Stimulator from Dimocarpus longan, Its Structural Modification, and Structure–Activity Relationships for Vitiligo

Autor:	Jae-Won Song, Sunju Choi, Gayeong Kim, Hyang Bok Lee, P. Sankara Rao, Jeonghyun Shin, Eun Ki Kim, Dong-Gyu Cho
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	melanoblast stimulator melanogenesis vitiligo structure–activity relationships Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 7, p 2135 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27072135
Popis:	A novel melanoblast stimulator (1) was isolated from Dimocarpus longan. Its analogs were also synthesized to support a new furan-based melanoblast stimulator scaffold for treating vitiligo. Isolated 5-(hydroxymethyl)furfural (HMF, 1) is a well-known compound in the food industry. Surprisingly, the melanogenic activity of HMF (1) was discovered here for the first time. Both HMF and its synthetic analog (16) promote the differentiation and migration of melanoblasts in vitro. Typically, stimulator (1) upregulated MMP2 expression, which promoted the migration of melanoblasts in vitro.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9ee17b5984474b37b34ba22b7197dd6b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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