Territorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China
| Autor: | Kenneth Siu-Sing Leung, Timothy Ting-Leung Ng, Alan Ka-Lun Wu, Miranda Chong-Yee Yau, Hiu-Yin Lao, Ming-Pan Choi, Kingsley King-Gee Tam, Lam-Kwong Lee, Barry Kin-Chung Wong, Alex Yat Man Ho, Kam-Tong Yip, Kwok-Cheung Lung, Raymond Wai-To Liu, Eugene Yuk-Keung Tso, Wai-Shing Leung, Man-Chun Chan, Yuk-Yung Ng, Kit-Man Sin, Kitty Sau-Chun Fung, Sandy Ka-Yee Chau, Wing-Kin To, Tak-Lun Que, David Ho-Keung Shum, Shea Ping Yip, Wing Cheong Yam, Gilman Kit-Hang Siu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Emerging Infectious Diseases, Vol 27, Iss 1, Pp 196-204 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1080-6040 1080-6059 |
| DOI: | 10.3201/eid2701.201543 |
| Popis: | Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10−3 substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread. |
| Databáze: | Directory of Open Access Journals |
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