| Autor: |
Rong-zu Nie, Mei-zhu Dang, Kai-kai Li, Jin-ming Peng, Jing Du, Meng-ying Zhang, Chun-mei Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 52, Iss , Pp 492-504 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2018.11.018 |
| Popis: |
A-type EGCG dimer is a new proanthocyanidins dimer from persimmon fruits. In the present study, we firstly examined the effects of EGCG and A-type EGCG dimer on Aβ40-fibrillization, and then the detailed mechanisms behind the inhibitory effects of polyphenols on Aβ40 amyloid fibrils formation were investigated by PICUP assay, ESI-MS, NMR and molecular docking. Our results confirmed that A-type EGCG dimer exhibited stronger inhibitory effect on the formation of Aβ40 amyloid fibrils. We found that A-type EGCG dimer possessed more binding sites on Aβ40 peptide than EGCG. Notably, compared with EGCG, A-type EGCG dimer could interact with more amino acid residues which possessed obvious aggregation-propensity. And our results also suggested that the hydrophobic interaction was the principal driving force to inhibit the formation of Aβ40 amyloid fibrils by A-type EGCG dimer. We believed that our study could provide useful insights for the design of low-molecular weight inhibitors of Aβ aggregation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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