The relationship between congenital heart disease and cancer in Swedish children: A population-based cohort study.

Autor: Christina-Evmorfia Kampitsi, Hanna Mogensen, Maria Feychting, Giorgio Tettamanti
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: PLoS Medicine, Vol 19, Iss 2, p e1003903 (2022)
Druh dokumentu: article
ISSN: 1549-1277
1549-1676
DOI: 10.1371/journal.pmed.1003903
Popis: BackgroundBirth defects have been consistently associated with elevated childhood cancer risks; however, the relationship between congenital heart disease (CHD) and childhood cancer remains conflicting. Considering the increasing patient population with CHD after improvements in their life expectancies, insights into this relationship are particularly compelling. Thus, we aimed to determine the relationship between CHD and cancer in Swedish children.Methods and findingsAll individuals registered in the Swedish Medical Birth Register (MBR) between 1973 and 2014 were included in this population-based cohort study (n = 4,178,722). Individuals with CHD (n = 66,892) were identified from the MBR and National Patient Register, whereas cancer diagnoses were retrieved from the Swedish Cancer Register. The relationship between CHD and childhood cancer (ConclusionsWe found associations between CHD and childhood lymphomas and hepatoblastomas not explained by a diagnosis of Down syndrome. Stronger associations were observed in complex CHD.
Databáze: Directory of Open Access Journals
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