A genome-wide association study reveals a polygenic architecture of speech-in-noise deficits in individuals with self-reported normal hearing

Autor:	Ishan Sunilkumar Bhatt, Juan Antonio Raygoza Garay, Srividya Grama Bhagavan, Valerie Ingalls, Raquel Dias, Ali Torkamani
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Speech-in-noise deficits Hidden hearing loss Age-related hearing difficulty in noise Self-reported speech perception Audiogram Hearing thresholds Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-63972-2
Popis:	Abstract Speech-in-noise (SIN) perception is a primary complaint of individuals with audiometric hearing loss. SIN performance varies drastically, even among individuals with normal hearing. The present genome-wide association study (GWAS) investigated the genetic basis of SIN deficits in individuals with self-reported normal hearing in quiet situations. GWAS was performed on 279,911 individuals from the UB Biobank cohort, with 58,847 reporting SIN deficits despite reporting normal hearing in quiet. GWAS identified 996 single nucleotide polymorphisms (SNPs), achieving significance (p
Databáze:	Directory of Open Access Journals
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