Multiple HLA-matched platelet transfusions for a single patient with broad anti-HLA antibodies: a case report

Autor:	Takeshi Hagino, Nelson Hirokazu Tsuno, Fumihiro Azuma, Hideo Ohtani, Reina Matsui, Chie Someya, Yutaka Kato, Satoko Osanai, Hiroko Hidai, Hisashi Tsutsumi, Hideki Akiyama, Sayuri Motomura, Tetsunori Tasaki
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	abh-compatible platelet units anti-hla antibody corrected count increment crossmatch-positive platelet units platelet transfusion refractoriness Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Platelets, Vol 30, Iss 6, Pp 799-801 (2019)
Druh dokumentu:	article
ISSN:	0953-7104 1369-1635 09537104
DOI:	10.1080/09537104.2019.1609664
Popis:	The efficacy of 30 platelet concentrate (PC) products transfused to a patient with myelodysplastic syndrome (MDS) was evaluated by calculating the 1-hour post-transfusion corrected count increment (1h-CCI). Of the 30 transfusions, all HLA-A/B-matched, the cross-match (CM) test was negative in 23 (CM(-)-PC) and weakly positive (CM(+)-PC) in 2, and the CM test was not conducted in 5 (non-CM-PC). The effective rate was higher with CM(-)-PC compared to non-CM-PC (82.6% vs 60%), but statistical significance was not achieved, which suggested that the CM test of PC may still be a not satisfactorily effective predictor of PC refractoriness. Studies are ongoing in Japan to confirm on the importance of CM test of PC.
Databáze:	Directory of Open Access Journals
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