| Autor: |
Emilie Charton, Jean‐Baptiste Bachet, Pascal Hammel, Jérôme Desramé, Benoist Chibaudel, Romain Cohen, Philippe Debourdeau, Jérome Dauba, Thierry Lecomte, Jean‐François Seitz, Christophe Tournigand, Thomas Aparicio, Véronique Guerin‐Meyer, Julien Taieb, Julien Volet, Christophe Louvet, Amélie Anota, Franck Bonnetain |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Cancer Medicine, Vol 8, Iss 11, Pp 5079-5088 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2045-7634 |
| DOI: |
10.1002/cam4.2311 |
| Popis: |
Abstract Background The phase II AFUGEM GERCOR trial aimed to assess the efficacy of a first‐line therapy combining nab‐paclitaxel plus either gemcitabine (gemcitabine group) or simplified leucovorin and fluorouracil (sLV5FU2 group) in patients with previously untreated metastatic pancreatic cancer. Results of progression‐free survival at 4 months (primary endpoint) were in favor of the sLV5FU2 group. This paper presents health‐related quality of life (HRQoL) data as a secondary endpoint. Methods HRQoL was assessed using the EORTC QLQ‐C30 questionnaire at baseline and at each chemotherapy cycle until the end of treatment. The HRQoL deterioration‐free survival (QFS) was used as a modality of longitudinal analysis. QFS was defined as the time between randomization and the first definitive HRQoL score deterioration as compared to the baseline score, or death. Sensitivity analysis was performed excluding death as an event. Univariate Cox models were used to estimate hazard ratios (HRs) and 90% confidence intervals (CIs) of the treatment effect. Results Between 2013 and 2014, 114 patients were randomized in a 1:2 ratio (39 in the gemcitabine group and 75 in the sLV5FU2 group). Patients in the sLV5FU2 group seemed to present longer QFS than those of the gemcitabine group for 14 out of 15 dimensions, with HRs |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
