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Mohmad H Alsabani,1,2 Badi A Alotaibi,2,3 Lafi H Olayan,1,2 Abdulrhman S Alghamdi,2,4 Malik A Alshammasi,1 Bassam Abdulrahman Alqasir,1 Salman Madyan Alrashidi,1 Majed Saad Alshugair,1 Mohammed K Al Harbi2,5,6 1Anesthesia Technology Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 2King Abdullah International Medical Research Centre, Riyadh, Saudi Arabia; 3Clinical Laboratory Sciences Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 4Emergency Medical Services Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 5Department of Anesthesia, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; 6College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi ArabiaCorrespondence: Mohmad H Alsabani, Anesthesia Technology Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 11481, Saudi Arabia, Tel +966114298206, Email sabanim@ksau-hs.edu.saPurpose: Many risk factors, such as the duration of surgery and higher ASA scores, are associated with longer hospitalization in patients undergoing orthopedic surgery. However, no studies have evaluated the relationship between the preoperative systemic immune-inflammation index (SII) and length of hospital stay in orthopedic surgical patients. Therefore, this study aimed to investigate whether the SII is associated with the length of hospital stay in orthopedic surgery in adults.Patients and Methods: This was a retrospective cohort study, and data were extracted from electronic health records. Patients were included if they were older than 18 years and had undergone orthopedic surgery between [2016– 2021]. The patients were divided into two groups according to the median duration of hospitalization and according to SII cut-off value (high-SII group: ≥ 799.86, low-SII group: < 799.86). Univariate and multivariate linear regression analyses were used to identify the association between SII and length of hospitalization.Results: A total of 196 patients who underwent orthopedic surgery were included, and 62 were hospitalized for > 21 days. There were significant differences in terms of ASA score (P = 0.041). Patients who required a longer hospitalization of > 21 days had significantly lower hemoglobin level (P |
