Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy?

Autor: Ana Karina Soares Alves, Valéria Lanzoni, Rogério Aoki Fuziy, Rita Maria Aparecida Monteiro Moura Franco, Carlos Toshinori Maeda, Gaspar de Jesus Lopes Filho, Marcelo Moura Linhares
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Acta Cirúrgica Brasileira, Vol 32, Iss 7, Pp 515-522 (2017)
Druh dokumentu: article
ISSN: 0102-8650
DOI: 10.1590/s0102-865020170070000002
Popis: Abstract Purpose: To evaluate the effects of mesenchymal stem cells on liver regeneration in rats following a 70% hepatectomy. Methods: Forty rats were subjected to 70% hepatectomy and then ~106 mesenchymal stem cells (test group), or saline solution (control group), were infused into their livers via the portal vein. Each treatment group was divided into early and late subgroups (euthanized 3 d and 5 d following the operation, respectively). Group comparisons of Albumin, aminotransaminases (AST, ALT), and Alcaline Phosphatase (AP) levels, proliferative index (ki-67+ straining), and mitotic cell counts were conducted. Results: No significant differences in liver regeneration rate, number of mitoses, proliferative index, or serum levels of albumin, AST, or AP were observed. ALT levels were higher in the test group than in the control group (p
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