Association of WDR79 (rs2287497C>T) Poly-morphism with Breast Cancer Susceptibility in Northwest of Iran
| Autor: | Zahra Ebadi, Sara Ghaffarian |
|---|---|
| Jazyk: | English<br />Persian |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Iranian South Medical Journal, Vol 26, Iss 1, Pp 1-13 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1735-4374 1735-6954 |
| Popis: | Background: The WDR79 gene encodes an antisense RNA which it is essential for stabilization and in-duction of p53 gene. WDR79 gene Single nucleotide polymorphisms are associated with cancer risk. This study was done to assess the association of WDR79 (rs2287497C>T) gene polymorphism with the risk and prognosis of breast cancer in women’s of northwest Iran. Materials and Methods: In this case-control study, the association of WDR79 (rs2287497C>T) gene pol-ymorphism with breast cancer susceptibility was studied in a statistical population consisting of 100 pa-tients and 100 healthy controls aged 19-76 years old by Tetra ARMS-PCR. Statistical analysis was per-formed using javastat online statistics package and SPSS V.26. Results: In the case group, the frequency of CC, TT, and TC genotypes were 76, 21, 3 percent respective-ly and they were 80, 18, and 2 percent for the control group. Also, C and T allele frequency in case group, was 86.5 and 13.5 percent and those in the control group were 89 and 11 percent respectively. Statistical analysis showed non-significant association between genotype and allele frequency and breast cancer. Also our results showed significant association between age and tumor size of patients with breast cancer in Northwestern Iran. Conclusion: These research findings suggest that WDR79 (rs2287497C>T) polymorphism of rs2287497C/T is not related to the risk of breast cancer. There was significant relationship between this SNP polymorphism and pathological characteristic including age and tumor size. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|