Soluble fms-like tyrosine kinase-1 and vascular endothelial growth factor: Novel markers for unexplained early recurrent pregnancy loss

Autor: Mahmoud Fathy Hassan
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Asian Pacific Journal of Reproduction, Vol 3, Iss 1, Pp 30-34 (2014)
Druh dokumentu: article
ISSN: 2305-0500
DOI: 10.1016/S2305-0500(13)60181-5
Popis: Objective: To evaluate the role of soluble fms-like tyrosine kinase-1 (sFlt-1) and vascular endothelial growth factor (VEGF) for prediction of pregnancy loss in patients with history of unexplained early recurrent pregnancy loss (RPL). Methods: A prospective case control study was conducted in 42 women with history of unexplained early RPL, and 170 pregnant controls with history of uncomplicated pregnancy. We measured maternal serum sFlt-1 and VEGF at gestational age 6–9 weeks as predictor for pregnancy loss. Results: Mean serum levels of sFlt-1 and VEGF were significantly higher in RPL group than controls (10439.7±385.4 vs 3304.5±104.8; P
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