| Autor: |
Joshua R. Fletcher, Colleen M. Pike, Ruth J. Parsons, Alissa J. Rivera, Matthew H. Foley, Michael R. McLaren, Stephanie A. Montgomery, Casey M. Theriot |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-020-20746-4 |
| Popis: |
The effects of antibiotics on the gut microbiota can lead to enhanced colonization of Clostridioides difficile (C. difficile) and toxin-mediated pathogenesis. Here, using defined toxin-mutant strains and a murine model, the authors provide insights into how toxin-induced inflammation alters C. difficile metabolism, host tissue gene expression and gut microbiota, together influencing a beneficial niche for infection. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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