Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program

Autor: Tanya T. Karagiannis, John P. Cleary, Busra Gok, Andrew J. Henderson, Nicholas G. Martin, Masanao Yajima, Elliot C. Nelson, Christine S. Cheng
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-16159-y
Popis: Over 100 million of opioid prescriptions are issued yearly in the USA alone, but the impact of opioid use on the immune system is barely characterized. Here the authors report antiviral immune response is blunted in several types of blood cells from opioid-dependent individuals, and when healthy donor cells are exposed to morphine in a dish.
Databáze: Directory of Open Access Journals