Extracorporeal Photopheresis Reduces Fibrotic and Inflammatory Transcriptomic Biological Marker of Chronic Antibody-mediated Kidney Rejection
| Autor: | Arnaud Lionet, MD, Marine Van Triempon, MD, Martin Figeac, MD, PhD, Victor Fages, MD, Jean-Baptiste Gibier, MD, PhD, François Provot, MD, Mehdi Maanaoui, MD, Nicolas Pottier, PharmD, PhD, Christelle Cauffiez, PhD, François Glowacki, MD, PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Transplantation Direct, Vol 10, Iss 3, p e1587 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2373-8731 00000000 |
| DOI: | 10.1097/TXD.0000000000001587 |
| Popis: | Background. The benefit of extracorporeal photopheresis on the course of kidney transplant rejection is unknown. The aim of our study was to investigate the variations in transcriptomics on graft biopsies when extracorporeal photopheresis was used to treat chronic humoral rejection after kidney transplantation. Methods. We retrospectively analyzed the mRNA expression of 770 genes of interest in graft biopsies performed before and after treatment. Eight patients received an average of 23 extracorporeal photopheresis sessions over 4 mo between the 2 biopsies. Results. Transcriptomic analysis of the graft biopsies identified a significant (adjusted P |
| Databáze: | Directory of Open Access Journals |
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