Evaluation of carotid intima media thickness in children with idiopathic nephrotic syndrome

Autor: Ashraf Sayed Kamel, Mohamed Mohamed Ezzat AlGhawass, Muhammad Adel Sayed, Sara Aly Roby
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Italian Journal of Pediatrics, Vol 48, Iss 1, Pp 1-8 (2022)
Druh dokumentu: article
ISSN: 1824-7288
DOI: 10.1186/s13052-022-01383-7
Popis: Abstract Background Nephrotic syndrome is the one of the commonest renal disorders in children. Children with nephrotic syndrome (NS) are at a high risk of atherosclerosis due to hyperlipidemia, hypertension. Carotid intima media thickness (CIMT) is a surrogate marker for atherosclerosis. This study aimed to evaluate the carotid intima media thickness in children with nephrotic syndrome and its relation to different risk factors. Methods This is an observational case control study that included forty children with nephrotic syndrome and thirty healthy children as controls. The inclusion criteria were: age of 2 years or more with disease duration of minimum of 1 year and glomerular filtration rate > 90 mL/min/1.73m2. CIMT was assessed by ultrasound. Lipid profile, protein/creatinine ratio in urine and kidney function tests were done. Results The mean CIMT (mm) was significantly higher in patients with NS (0.477 ± 0.04) compared to controls (0.39 ± 0.03) (P
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