Effectiveness of salt substitute on cardiovascular outcomes: A systematic review and meta‐analysis

Autor: Yi‐Ching Tsai, Yen‐Po Tsao, Chi‐Jung Huang, Yen‐Hsuan Tai, Yang‐Chin Su, Chern‐En Chiang, Shih‐Hsien Sung, Chen‐Huan Chen, Hao‐Min Cheng
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: The Journal of Clinical Hypertension, Vol 24, Iss 9, Pp 1147-1160 (2022)
Druh dokumentu: article
ISSN: 1751-7176
1524-6175
DOI: 10.1111/jch.14562
Popis: Abstract Hypertension‐related death is the leading cause of mortality worldwide, making blood pressure (BP) control an important issue. Salt substitute is a non‐pharmaceutical strategy to improve hypertension control. The goal of this study was to evaluate the effect of salt substitute on BP and cardiovascular disease. The authors searched the Cochrane Library and PubMed databases through March 2022, and assessed the risk‐of‐bias for included studies by the Cochrane risk‐of‐bias tool. Twenty‐three randomized controlled trials with 32073 patients were included in our systematic review. A meta‐analysis with random effects was performed to analyze the effects of salt substitute on systolic and diastolic BP, 24‐h urinary sodium and potassium, and cardiovascular and all‐cause mortality. In the random‐effects model, participants consuming salt substitute showed significant reduction in systolic BP (mean difference (MD) −4.80 mmHg, 95% confidence interval (CI) −6.12 to −3.48, P
Databáze: Directory of Open Access Journals
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