DFFNDDS: prediction of synergistic drug combinations with dual feature fusion networks

Autor:	Mengdie Xu, Xinwei Zhao, Jingyu Wang, Wei Feng, Naifeng Wen, Chunyu Wang, Junjie Wang, Yun Liu, Lingling Zhao
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Drug combination Synergistic effect Deep learning Dual-feature fusion Information technology T58.5-58.64 Chemistry QD1-999
Zdroj:	Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-12 (2023)
Druh dokumentu:	article
ISSN:	1758-2946
DOI:	10.1186/s13321-023-00690-3
Popis:	Abstract Drug combination therapies are promising clinical treatments for curing patients. However, efficiently identifying valid drug combinations remains challenging because the number of available drugs has increased rapidly. In this study, we proposed a deep learning model called the Dual Feature Fusion Network for Drug–Drug Synergy prediction (DFFNDDS) that utilizes a fine-tuned pretrained language model and dual feature fusion mechanism to predict synergistic drug combinations. The dual feature fusion mechanism fuses the drug features and cell line features at the bit-wise level and the vector-wise level. We demonstrated that DFFNDDS outperforms competitive methods and can serve as a reliable tool for identifying synergistic drug combinations.
Databáze:	Directory of Open Access Journals
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