Cytological diagnosis of hyaline-vascular type of Castleman disease

Autor: Deepa Rani, Anupam Varshney, Kanika Rastogi
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Autopsy and Case Reports, Vol 14 (2024)
Druh dokumentu: article
ISSN: 2236-1960
DOI: 10.4322/acr.2024.519
Popis: Castleman disease (CD) is a rare, benign lymphoproliferative disorder, mostly involving the mediastinal lymph nodes, but can occur wherever lymphoid tissue is found. With only a few published case reports, there needs to be more literature on its cytological findings. We report the case of a 63-year-old female presenting with left upper cervical swelling. Fine needle aspiration cytology smears showed variably sized lymphoid follicles with diminished germinal centers, prominence of follicular dendritic cells, and capillaries traversing some of the follicles. The possibility of a hyaline-vascular type of Castleman disease was suggested. Histopathology confirmed the cytological diagnosis. The index case is being presented to discuss the cytological features of the CD along with its histological and immunohistochemical correlation.
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