Nimesulide Based Novel Glycolamide Esters: Their Design, Synthesis, and Pharmacological Evaluation

Autor:	Kavitha Kankanala, Vangala Ranga Reddy, Yumnam Priyadarshini Devi, Lakshmi Narasu Mangamoori, Khagga Mukkanti, Sarbani Pal
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Chemistry QD1-999
Zdroj:	Journal of Chemistry, Vol 2013 (2013)
Druh dokumentu:	article
ISSN:	2090-9063 2090-9071
DOI:	10.1155/2013/816769
Popis:	The nimesulide based novel glycolamide esters were designed and synthesized for the first time via a three-step method starting from nimesulide. Structures of the synthesized compounds were confirmed by spectroscopic analysis. All the synthesized compounds were examined for their cytotoxic effects in vitro, some of which showed significant cytotoxic activities against HCT-15 human colon cancer cell line.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c9e45477267e4d179e2d1395aaba8e20 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF