Synthesis and characterization of curcumin-encapsulated loaded on carboxymethyl cellulose with docking validation as α-amylase and α-glucosidase inhibitors
| Autor: | Almehizia Abdulrahman A., Al-Omar Mohamed A., Al-Obaid Abdulrahman M., Naglah Ahmed M., Bhat Mashooq A., Ghabbour Hazem A., Khatab Tamer K., Hassan Ashraf S. |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Polish Journal of Chemical Technology, Vol 26, Iss 3, Pp 63-69 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1899-4741 2024-0031 |
| DOI: | 10.2478/pjct-2024-0031 |
| Popis: | In reaction to the expanding predominance of diabetes mellitus, curcumin nanoparticles stacked on carboxymethyl cellulose (CMC) composite were effectively synthesized, characterized, and examined utilizing UV/Vis and FTIR spectroscopy combined with transmission electron microscopy (TEM). The bioactivity of curcumin (Cur), carboxymethyl cellulose (CMC), and curcumin nanoparticles stacked with carboxymethyl cellulose (CUR-CMC) was tried through atomic docking approval as an α-amylase and α-glucosidase inhibitor. The conclusion illustrated that the curcumin-supported CMC is more potent than CUR itself self the validation presented is compared with acarbose as a reference molecule and then CUR-CMC can presented as promising in curing hyperglycemia by decreasing the absorption of glucose. |
| Databáze: | Directory of Open Access Journals |
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