Neuropathological Characterization of Dolphin Morbillivirus Infection in Cetaceans Stranded in Italy

Autor: Federica Giorda, Paola Crociara, Barbara Iulini, Paola Gazzuola, Alessandra Favole, Maria Goria, Laura Serracca, Alessandro Dondo, Maria Ines Crescio, Tania Audino, Simone Peletto, Cristina Esmeralda Di Francesco, Maria Caramelli, Eva Sierra, Fabio Di Nocera, Giuseppe Lucifora, Antonio Petrella, Roberto Puleio, Sandro Mazzariol, Giovanni Di Guardo, Cristina Casalone, Carla Grattarola
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Animals, Vol 12, Iss 4, p 452 (2022)
Druh dokumentu: article
ISSN: 12040452
2076-2615
DOI: 10.3390/ani12040452
Popis: Cetacean morbillivirus (CeMV) is responsible for epidemic and endemic fatalities in free-ranging cetaceans. Neuro-inflammation sustained by CeMV is a leading cause of death in stranded cetaceans. A novel dolphin morbillivirus (DMV) strain of Atlantic origin circulating in Italian waters since early 2016 has caused acute/subacute lesions associated with positive immunolabelling of the virus. To date, myelin damage has not been fully documented and investigated in cetaceans. This study describes neuropathological findings in the brain tissue of 31 cetaceans found stranded along the Italian coastline and positive for DMV infection on molecular testing. Cell changes in the areas of myelinopathy were revealed by double indirect immunofluorescence. The most frequent DMV-associated lesions were astro-microgliosis, neuronal necrosis, spongiosis, malacia, and non-suppurative meningoencephalitis. Myelin reduction and areas of demyelination were revealed by means of a specific myelin biomarker. Morbilliviral antigen immunolabelling was mainly observed in neurons and microglial cells, in association with a marked activation of microglia and astrocytes. These findings extend our knowledge of DMV-associated brain lesions and shed light on their pathogenesis.
Databáze: Directory of Open Access Journals
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