Therapeutic strategy for pandrug-resistant Klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimen

Autor:	Alessandra Oliva, Maria T. Mascellino, Alessia Cipolla, Alessandra D’Abramo, Annalisa De Rosa, Stefano Savinelli, Maria Rosa Ciardi, Claudio M. Mastroianni, Vincenzo Vullo
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Double carbapenem Colistin Pan-drug resistant K. pneumoniae Bloodstream infection Infectious and parasitic diseases RC109-216
Zdroj:	International Journal of Infectious Diseases, Vol 33, Iss C, Pp 132-134 (2015)
Druh dokumentu:	article
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2015.01.011
Popis:	Infections due to carbapenemase-producing Klebsiella pneumoniae represent an emerging threat due to the high mortality rate and lack of valid antimicrobial combinations, especially when the strain is colistin-resistant. We report a case of bloodstream infection due to pandrug-resistant K. pneumoniae treated successfully with an innovative regimen comprising a combination of colistin plus double carbapenem, along with an in vitro analysis showing the synergistic and bactericidal effect.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9e29b58bf60b466eb82d03ced9eb0f43 Zobrazit plný text záznamu View record in DOAJ