Unusual Cause of Childhood Anemia: Imerslund Grasbeck Syndrome
| Autor: | Kishan Prasad Hosapatna Laxminarayana, Sunil Kumar Yeshvanth, Jayaprakash K Shetty, Harish S Permi, Chandrika Rao |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Journal of Laboratory Physicians, Vol 3, Iss 02, Pp 113-115 (2011) |
| Druh dokumentu: | article |
| ISSN: | 0974-2727 0974-7826 |
| DOI: | 10.4103/0974-2727.86845 |
| Popis: | Imerslund Grasbeck syndrome (IGS) is a rare autosomal recessive childhood disorder characterized by selective Vitamin (vit) B 12 malabsorption with asymptomatic proteinuria without any structural renal pathology. The patients stay healthy for decades with life-long parenteral vit B12. We report a case of young female who presented with pancytopenia and proteinuria, evaluated in local hospitals as chronic hemolytic anemia (autoimmune cause), finally diagnosed as IGS on complete evaluation. She was treated with injectable vit B12 (1000 μg cyanocobalalmin) and showed drastic recovery. IGS should be considered in patients with megaloblastic anemia not responding to oral vit B12 and associated proteinuria. |
| Databáze: | Directory of Open Access Journals |
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