Challenge and Outcome for the Prostate Squamous Cell Carcinoma Which Developed 8 Years after Low-Dose-Rate Brachytherapy Approached by a Combined Multimodal Treatment with High-Dose-Rate Interstitial Brachytherapy, External Beam Radiation Therapy, and Chemotherapy

Autor: Toru Matsugasumi, Koji Masui, Kaori Yamada, Sho Watanabe, Koji Okihara, Nana Kozawa, Yasuhiro Yamada, Hideya Yamazaki, Kei Yamada, Osamu Ukimura
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Case Reports in Oncology, Vol 14, Iss 2, Pp 854-860 (2021)
Druh dokumentu: article
ISSN: 1662-6575
DOI: 10.1159/000516034
Popis: Prostate squamous cell carcinoma (pSCC) rarely develops as a secondary cancer after treatment with low-dose-rate brachytherapy (LDR-BT). There is no established effective treatment for the disease condition. Herein, we present a 78-year-old man who developed pSCC 8 years after LDR-BT. He was subsequently selected to receive a combined multimodal treatment with high-dose-rate interstitial brachytherapy (HDR-ISBT), external beam radiation therapy, and chemotherapy for his pSCC. Eleven months later, he displayed no biochemical failure nor clinical radiographic recurrence. However, MRI detected a newly developed prostatic-rectal fistula (grade 4), and a colostomy was performed to relieve pain and inflammation. To our knowledge, this is the first report to perform a combined multimodal treatment with HDR-ISBT for pSCC suspected as a secondary cancer due to LDR-BT.
Databáze: Directory of Open Access Journals
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