Plasma EBV DNA: A Promising Diagnostic Marker for Endemic Burkitt Lymphoma

Autor: Rena R. Xian, Tobias Kinyera, Isaac Otim, Joshua N. Sampson, Hadijah Nabalende, Ismail D. Legason, Jennifer Stone, Martin D. Ogwang, Steven J. Reynolds, Patrick Kerchan, Kishor Bhatia, James J. Goedert, Sam M. Mbulaiteye, Richard F. Ambinder
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Frontiers in Oncology, Vol 11 (2021)
Druh dokumentu: article
ISSN: 2234-943X
DOI: 10.3389/fonc.2021.804083
Popis: Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in regions of equatorial Africa where P. falciparum malaria is holoendemic. The tumor is consistently associated with Epstein-Barr virus (EBV). Screening for EBV DNA in plasma in a high-risk population in Hong Kong has been shown to be useful in facilitating the early diagnosis of nasopharyngeal carcinoma, another EBV-associated tumor. Here, we investigate plasma EBV as a diagnostic marker for eBL in children in Uganda. We studied plasma specimens from 25 children with eBL and 25 controls matched for age (
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