| Autor: |
Tzemach Aouizerat, Daniel Gelman, Amir Szitenberg, Itay Gutman, Shunit Glazer, Eli Reich, Miriam Schoemann, Rachel Kaplan, Amijai Saragovi, Ronen Hazan, Michael Klutstein |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 19, Iss , Pp 545-558 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2019.08.002 |
| Popis: |
Summary: The Growth Advantage in Stationary Phase (GASP) phenomenon, described in bacteria, reflects the genetic adaptation of bacteria to stress, including starvation, for a long time. Unlike in stationary phase where no cell division occurs, GASP harbors active cell division, concurrent with genetic adaptation.Here we show that GASP occurs also in eukaryotes.Two strains of Saccharomyces cerevisiae (Sc404 and Sc424) have been isolated from 2-year-old sealed bottles of beer. These strains presented advantage in survival and growth over the parent during stress. The differences between the strains are irreversible and therefore genetic in origin rather than epigenetic. Direct competition assays show that Sc404 and Sc424 outcompete the parent in direct competition. DNA sequencing shows changes of the genome: the TOR complexes are mutated, and DNA repair gene mutations confer a mutator phenotype. The differences between the strains are reflected in a difference in taste between beers brewed from them. : Biological Sciences; Genetics; Microbiology; Microbial Genetics; Molecular Microbiology; Cell Biology Subject Areas: Biological Sciences, Genetics, Microbiology, Microbial Genetics, Molecular Microbiology, Cell Biology |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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