A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX

Autor: Misato Araki, Koshi Matsui, Kohji Takagi, Emi Kanaya, Shinichi Sekine, Shiho Nagasawa, Toru Watanabe, Takeshi Miwa, Katsuhisa Hirano, Takamichi Igarashi, Haruyoshi Tanaka, Kazuto Shibuya, Isaya Hashimoto, Shozo Hojo, Isaku Yoshioka, Tomoyuki Okumura, Kenichi Hirabayashi, Tsutomu Fujii
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Surgical Case Reports, Vol 9, Iss 1, Pp 1-5 (2023)
Druh dokumentu: article
ISSN: 2198-7793
DOI: 10.1186/s40792-023-01719-3
Popis: Abstract Background Squamous cell carcinoma (SCC) of the breast is a rare form of breast cancer, accounting for approximately 0.1% of all breast cancers. It is known for its rapid tumor growth and poor prognosis with no established treatment. Case presentation A 56-year-old woman was diagnosed with breast SCC with axillary, supraclavicular and internal thoracic lymph node metastases. She received neoadjuvant chemotherapy (NAC) with dose-dense doxorubicin and cyclophosphamide (AC) followed by dose-dense paclitaxel (PTX). This treatment resulted in a pathological complete response (pCR) after breast-conserving surgery. The patient was then treated with radiotherapy. She remained free of recurrence for three years postoperatively. Conclusions We report a rare case of breast SCC treated with preoperative dose-dense chemotherapy, resulting in pCR and allowing breast-conserving surgery.
Databáze: Directory of Open Access Journals