18F-FDG PET-CT for early detection of malignancies in patients with Li-Fraumeni Syndrome
| Autor: | Sonia Tereza Santos Nogueira, Eduardo Nóbrega Pereira Lima, Amanda França Nóbrega, Ivone do Carmo Gonçalves Torres, Marcelo eCavicchioli, Pierre eHainaut, Maria Isabel Waddington Achatz |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Frontiers in Oncology, Vol 5 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2234-943X 44970994 |
| DOI: | 10.3389/fonc.2015.00038 |
| Popis: | PurposeTo evaluate the effectiveness of 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) for detecting early cancer in carriers of germline TP53 mutation, the genetic defect underlying Li-Fraumeni and related syndromes (LFS/LFL) which predisposes to many forms of cancer throughout life.Patients and MethodsA total of 30 adult patients from 6 families with germline TP53 mutations were recruited. These patients did not have a diagnosis of cancer in the 24 months preceding the study. Anomalous concentrations from whole-body 18F-FDG-PET/CT were assessed by two independent experts. Suspicious lesions were excised and subjected to pathological examination. ResultsA total of 6/30 patients showed abnormal 18F-FDG-concentration. Confirmation studies revealed three cases of cancer, including one lung cancer, one ovarian cancer and one disseminated breast cancer. Three patients had non-malignant lesions (one Bartholin’s cyst and two cases of reactive lymph nodes).Conclusions18F-FDG-PET/CT is effective in detecting cancer in subjects who are asymptomatic according to current screening guidelines. These results further suggest that 18F-FDG-PET/CT is an appropriate method for surveillance of cancer risk in TP53 mutation carriers. |
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