| Autor: |
Daniel Jacko, Lukas Masur, Kirill Schaaf, Jonas Zacher, Käthe Bersiner, Markus deMarées, Wilhelm Bloch, Sebastian Gehlert |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Physiological Reports, Vol 12, Iss 3, Pp n/a-n/a (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2051-817X |
| DOI: |
10.14814/phy2.15922 |
| Popis: |
Abstract Lipofuscin (LF) is an intracellular aggregate associated with proteostatic impairments, especially prevalent in nondividing skeletal muscle fibers. Reactive oxygen species (ROS) drive LF‐formation. Resistance training (RT) improves muscle performance but also increases ROS production, potentially promoting LF‐formation. Thus, we aimed to investigate if RT of a mesocycle duration increases LF‐formation in type‐I and II muscle fibers and whether RT increases the antioxidant capacity (AOC) in terms of SOD1 and SOD2 content. An intervention group (IG) performed 14 eccentrically accented RT‐sessions within 7 weeks. Vastus lateralis muscle biopsies were collected before and after the intervention from IG as well as from a control group (CG) which refrained from RT for the same duration. LF was predominantly found near nuclei, followed by membrane‐near and a minor amount in the fiber core, with corresponding spot sizes. Overall, LF‐content was higher in type‐I than type‐II fibers (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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