A study to assess anti-inflammatory effect of Vitamin D on gingivitis: A dose dependent randomised controlled trial

Autor: Rahul Srivastava, Hadi Raza, Pooja Kabra, Ashtha Arya, Athira Purushothaman, Pallavi A Thomas
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Pharmacy and Bioallied Sciences, Vol 15, Iss 6, Pp 1182-1184 (2023)
Druh dokumentu: article
ISSN: 0975-7406
DOI: 10.4103/jpbs.jpbs_169_23
Popis: Introduction: Vitamin D deficiency increases gingivitis risk. Studies show that higher vitamin D levels reduce inflammation. Materials and Methods: College conducted a double-blind, randomized, controlled trial on 451 people's vitamin D and gingival health at baseline. For three months, participants were given a placebo (group A), 1000 international units (IU) of vitamin D3 per day (group B), 500 IU per day (group C), or 2000 IU per day (group A). Gingival scores were recorded for three months to assess the anti-inflammatory effect (the first, second, and third). Vitamin D levels also affected gingivitis. Results: Vitamin D dose-dependently reduces gingivitis inflammation. Vitamin D administration negatively correlated with gingival index score. Anti-inflammatory vitamin D levels are 32–37 ng/ml. Conclusion: Vitamin D supplementation can reduce gingivitis severity. The optimal blood vitamin D level is 30–35 ng/ml.
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