Effect of Metformin on Premature Luteinization and Pregnancy Outcomes in Intracytoplasmic Sperm Injection-Fresh Embryo Transfer Cycles: A Randomized Double-Blind Controlled Trial
| Autor: | Reda S. Hussein, Ihab Elnashar, Ahmed F Amin, Yulian Zhao, Ahmed M. Abdelmagied, Ahmed M. Abbas, Ahmed A. Abdelaleem, Tarek A. Farghaly, Osama S Abdalmageed, Ahmed A. Youssef, Esraa Badran, Hisham A. Abou-Taleb |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | International Journal of Fertility and Sterility, Vol 15, Iss 2, Pp 108-114 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2008-076X 2008-0778 |
| DOI: | 10.22074/ijfs.2020.134643 |
| Popis: | Background: Premature luteinization (PL) is not unusual in in vitro fertilization (IVF) and could not be whollyavoided by using either gonadotropin-releasing hormone (GnRH) agonists or GnRH antagonist regimens. The studyaims to evaluate metformin’s efficacy in preventing PL in fresh GnRH antagonist intracytoplasmic sperm injection(ICSI) cycles with cleavage-stage embryo transfer.Materials and Methods: This randomized, double-blind, placebo-controlled trial was conducted in a tertiary universityIVF center. We recruited infertile women who were scheduled to perform their first or second ICSI trial. Eligiblewomen were recruited and randomized in a 1:1 ratio into two groups. Metformin was administered in a dose of 1500mg per day since the start of contraceptive pills in the cycle antecedent to stimulation cycle until the day of ovulationtriggering, while women in the placebo group received a placebo for the same regimen and duration. The primaryoutcome was the incidence of PL, defined as serum progesterone (P) on the triggering day ≥1.5 ng/mL. Secondaryoutcomes comprised the live birth, ongoing pregnancy, implantation, and good-quality embryos rates.Results: The trial involved 320 eligible participants (n=160 in each group). Both groups had comparable stimulationdays, endometrial thickness, peak estradiol levels, number of oocytes retrieved, and number of mature oocytes. Metformingroup experienced lower level of serum P (p |
| Databáze: | Directory of Open Access Journals |
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