Autor: |
Stefano Ziccardi, Helen Genova, Elisa Colato, Maddalena Guandalini, Agnese Tamanti, Massimiliano Calabrese |
Jazyk: |
angličtina |
Rok vydání: |
2024 |
Předmět: |
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Zdroj: |
Annals of Clinical and Translational Neurology, Vol 11, Iss 7, Pp 1798-1808 (2024) |
Druh dokumentu: |
article |
ISSN: |
2328-9503 |
DOI: |
10.1002/acn3.52085 |
Popis: |
Abstract Objective Cognitive and affective symptoms in multiple sclerosis (MS) can be independently impaired and have different pathways of progression. Cognitive alterations have been described since the earliest MS stages; by contrast, the social cognition (SC) domain has never been investigated in the first year from MS diagnosis. We aimed to evaluate SC and unravel its neural bases in newly diagnosed MS patients. Methods Seventy MS patients underwent at diagnosis a 3 T‐MRI and a neuropsychological/SC assessment (median time between diagnosis and MRI/cognitive evaluation = 0 months). We tested two matched reference samples: 31 relapsing–remitting MS patients with longer course (mean ± SD disease duration = 7.0 ± 4.5 years) and 38 healthy controls (HCs). Cortical thicknesses (CTh) and volumes of brain regions were calculated. Results Newly diagnosed MS patients performed significantly lower than HCs in facial emotion recognition (global: p |
Databáze: |
Directory of Open Access Journals |
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