Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications

Autor: Hyunil Ryu, Ahmed Fuwad, Sunhee Yoon, Huisoo Jang, Jong Chan Lee, Sun Min Kim, Tae-Joon Jeon
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: International Journal of Molecular Sciences, Vol 20, Iss 6, p 1437 (2019)
Druh dokumentu: article
ISSN: 1422-0067
DOI: 10.3390/ijms20061437
Popis: In biological cells, membrane proteins are the most crucial component for the maintenance of cell physiology and processes, including ion transportation, cell signaling, cell adhesion, and recognition of signal molecules. Therefore, researchers have proposed a number of membrane platforms to mimic the biological cell environment for transmembrane protein incorporation. The performance and selectivity of these transmembrane proteins based biomimetic platforms are far superior to those of traditional material platforms, but their lack of stability and scalability rule out their commercial presence. This review highlights the development of transmembrane protein-based biomimetic platforms for four major applications, which are biosensors, molecular interaction studies, energy harvesting, and water purification. We summarize the fundamental principles and recent progress in transmembrane protein biomimetic platforms for each application, discuss their limitations, and present future outlooks for industrial implementation.
Databáze: Directory of Open Access Journals
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