| Autor: |
Mengyuan Liu, Ying Zhang, Ya Ruth Huo, Shuling Liu, Shuai Liu, Junwei Wang, Change Wang, Jinhuan Wang, Yong Ji |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Dementia and Geriatric Cognitive Disorders Extra, Vol 4, Iss 3, Pp 450-456 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1664-5464 |
| DOI: |
10.1159/000367596 |
| Popis: |
Background/Aim: Recent data have indicated that the rs1080985 single nucleotide polymorphism (SNP) of the cytochrome P450 (CYP) 2D6 and the common apolipoprotein E (APOE) gene may affect the response to donepezil in patients with Alzheimer's disease (AD). We investigated this association in Chinese patients with mild-to-moderate AD. Methods: In this prospective cohort study, analyses of CYP2D6 and APOE were conducted in 208 native Chinese patients with mild-to-moderate AD. All patients were treated with donepezil 5 mg/day for 6 months, and the response to treatment was assessed using the Mini-Mental State Examination. Results: No significant differences between responders (68.9%) and nonresponders (31.1%) to donepezil treatment (6 months' duration) were observed in the distribution of the CYP2D6 rs1080985 SNP, common APOE polymorphism or a combination of the two. Conclusions: Our results suggest that neither the CYP2D6 nor the APOE polymorphism influences the 6-month response to donepezil treatment in a Chinese population with AD. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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