Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure

Autor: Kun Zhao, Yaowang Li, Zhenying Liu, Houfang Long, Chunyu Zhao, Feng Luo, Yunpeng Sun, Youqi Tao, Xiao-dong Su, Dan Li, Xueming Li, Cong Liu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-16386-3
Popis: The E46K α-synuclein mutation causes familial Parkinson’s disease. Here, the authors present the cryo-EM structure of N-terminally acetylated E46K α-synuclein fibrils and find that it is distinct from other known α-synuclein fibril structures.
Databáze: Directory of Open Access Journals