| Autor: |
Zoltan Kender, Johann M. E. Jende, Felix T. Kurz, Dimitrios Tsilingiris, Lukas Schimpfle, Alba Sulaj, Ekaterina von Rauchhaupt, Hannelore Bartl, Christoph Mooshage, Jens Göpfert, Peter Nawroth, Stephan Herzig, Julia Szendroedi, Martin Bendszus, Stefan Kopf |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Frontiers in Endocrinology, Vol 14 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1664-2392 |
| DOI: |
10.3389/fendo.2023.1046690 |
| Popis: |
BackgroundDiabetic sensorimotor polyneuropathy (DSPN) is one of the most prevalent and poorly understood diabetic microvascular complications. Recent studies have found that fractional anisotropy (FA), a marker for microstructural nerve integrity, is a sensitive parameter for the structural and functional nerve damage in DSPN. The aim of this study was to investigate the significance of proximal sciatic nerve’s FA on different distal nerve fiber deficits of the upper and lower limbs and its correlation with the neuroaxonal biomarker, neurofilament light chain protein (NfL).Materials and methodsSixty-nine patients with type 2 diabetes (T2DM) and 30 healthy controls underwent detailed clinical and electrophysiological assessments, complete quantitative sensory testing (QST), and diffusion-weighted magnetic resonance neurography of the sciatic nerve. NfL was measured in the serum of healthy controls and patients with T2DM. Multivariate models were used to adjust for confounders of microvascular damage.ResultsPatients with DSPN showed a 17% lower sciatic microstructural integrity compared to healthy controls (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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