| Autor: |
Joshua Millar, Luke Gibbons, Catia Costa, Ella Schneider, Johanna von Gerichten, Melanie J. Bailey, Susan Campbell, Catherine Duckett, Sarah Doyle, Laura M. Cole |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Analytica, Vol 4, Iss 3, Pp 264-279 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2673-4532 |
| DOI: |
10.3390/analytica4030021 |
| Popis: |
The metallome has been involved in the pathological investigation into ocular tissue for decades; however, as technologies advance, more information can be ascertained from individual tissue sections that were not previously possible. Herein, a demonstration of complementary techniques has been utilized to describe the distribution and concentrations of essential metals in both wildtype (WT) and rhodopsin (Rho−/−) ocular tissues. The multimodal approach described is an example of complementary datasets that can be produced when employing a multifaceted analytical approach. Heterogenous distributions of copper and zinc were observable within both WT and Rho−/− tissue by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), and the distributions of further trace elements notoriously problematic for ICP-MS analysis (phosphorous, Sulfur, chlorine, potassium, calcium, iron, and aluminum) were analysed by particle-induced X-ray emission (PIXE). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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