| Autor: |
Ikumi Yanagita, Yuya Fujihara, Chikayo Iwaya, Yuichi Kitajima, Misuzu Tajima, Masanao Honda, Yuji Teruya, Hideko Asakawa, Tomoko Ito, Terumi Eda, Noriko Yamaguchi, Yumi Kayashima, Mihoko Yoshimoto, Mayumi Harada, Shoji Yoshimoto, Eiji Aida, Toshihiko Yanase, Hajime Nawata, Kazuo Muta |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
BMC Geriatrics, Vol 20, Iss 1, Pp 1-8 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2318 |
| DOI: |
10.1186/s12877-020-01601-z |
| Popis: |
Abstract Background Frailty is broadly characterized by vulnerability and decline in physical, mental and social activities and is more common in elderly patients with type 2 diabetes mellitus (T2DM). Frailty is closely associated with nutrition, muscle strength, inflammation, and hormones etc. In hormones, dehydroepiandrosterone sulfate (DHEA-S) and cortisol are suggested to be such candidates affecting frailty. Little investigation has been performed using a wider range of measures of frailty to clarify risk factors for frailty including the above two hormones. Methods We performed a cross-sectional study to investigate the risk factors for frailty in elderly T2DM patients (n = 148; ≥65 years), using a broad assessment, the clinical frailty scale. We compared parameters between the non-frail and frail groups using the unpaired t and Mann-Whitney U tests. The Jonckheere-Therpstra test was used to identify relationships with the severity of frailty, and risk factors were identified using binary regression analysis. Results Simple regression analysis identified a number of significant risk factors for frailty, including DHEAS |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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