| Autor: |
Gemma Currie, Joanne Flynn, Morten Lindhardt, Harald Mischak, Peter Rossing, Christian Delles |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Artery Research, Vol 12 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1876-4401 |
| DOI: |
10.1016/j.artres.2015.10.228 |
| Popis: |
Background: Diabetic nephropathy (DN) is associated with cardiovascular disease. Microalbuminuria (MA), its traditional hallmark, reflects both renal and generalised vascular damage. We previously established a urinary proteomic classifier (CKD273) for early DN prediction that correlates with other biomarkers of renal function. Whether CKD273 only indicates renal damage or also generalised vascular disease remains unclear. Methods: We recruited 80 patients with type 2 diabetes (age, 62±7 years; blood pressure 138±11/79±8mmHg) free from cardiovascular complications with normal renal function (eGFR (88±15 ml/min/1.73m2) and normoalbuminuria (albumin: creatinine ratio (UACR), 5 (2-16) mg/g). Participants underwent measurement of carotid-femoral pulse wave velocity (PWV; SphygmoCor) and carotid intima media thickness (cIMT; ultrasound). Urinary proteomic analysis was performed by capillary electrophoresis coupled to mass spectrometry. Results: Mean CKD273 score (−0.234±0.376) was well below the pre-established cut-off (0.343) for diagnosis of DN. There was a trend towards higher CKD273 score in patients with UACR above the median (−0.160±0.372 vs −0.318±0.368; P=0.061). Median time from diabetes diagnosis was 11 (1–30) years; diabetes control was suboptimal (HbA1c, 62 (45–102) mmol/mol); and participants had subclinical vascular damage (PWV, 9.2 (6.4–12.5) m/s; cIMT, 0.850 (0.543–1.292) mm). As expected we saw a significant correlation between PWV and systolic blood pressure (r=0.259; P=0.024). The CKD273 classifier did not correlate with PWV (r=0.174; P=0.132) or cIMT (r=−0.096; P=0.415). Conclusion: CKD273 is not a marker of subclinical macrovascular disease in normoalbuminuric type 2 diabetic patients without overt cardiovascular complications. Our data provide further evidence that CKD273 is a specific marker of renal damage. |
| Databáze: |
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| Externí odkaz: |
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