Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety

Autor:	Aurel Pui, Marcel Popa, Valeriu Sunel, Lenuta Profire, Otilia Pintilie
Jazyk:	angličtina
Rok vydání:	2007
Předmět:	4-Thiadiazole 4-triazole thiosemicarbazide L-methionine antimicrobial activity Organic chemistry QD241-441
Zdroj:	Molecules, Vol 12, Iss 1, Pp 103-113 (2007)
Druh dokumentu:	article
ISSN:	12010103 1420-3049
DOI:	10.3390/12010103
Popis:	New 1,3,4-thiadiazole, 5a-e, and 1,2,4-triazolecompounds 6a-c, containing a D,L-methionine moiety were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides 4a-e in acid and alkaline media, respectively. The potential antimicrobial effects of the synthesized compounds were investigated using the Staphylococcus aureus ATCC 25923, Bacillus antracis ATCC 8705, Bacillus cereus ATCC 10987, Sarcina lutea ATCC 9341 and Escherichia coli ATCC 25922 strains. The newly synthesized compounds exhibited promising activities against Bacillus antracis and Bacillus cereus.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9d846e344d3a4c5cae2cc6dddd8f487b Zobrazit plný text záznamu View record in DOAJ