A Novel Method for Gene Expression Mapping of Metastatic Competence in Human Bladder Cancer
| Autor: | Z. Wu, M.S. Siadaty, G. Riddick, H.F. Frierson, Jr., J.K. Lee, W. Golden, S. Knuutila, G.M. Hampton, W. El-Rifai, D. Theodorescu |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 3, Pp 181-189 (2006) |
| Druh dokumentu: | article |
| ISSN: | 1476-5586 1522-8002 |
| DOI: | 10.1593/neo.05727 |
| Popis: | Expression profiling by DNA microarray analysis has provided insights into molecular alterations that underpin cancer progression and metastasis. Although differential expression of microarray-defined probes can be related to numerical or structural chromosomal alterations, it is unclear if such changes are also clustered in distinct chromosomes or genomic regions and whether chromosomal alterations always reflect changes in gene expression. Here we apply the dChip algorithm and a novel technique to test the hypothesis that expression changes occurring as a function of tumor progression and metastasis are nonrandomly distributed. Expression profiling of a human xenograff model of lung metastasis phenotype indicates that chromosomes 2, 11, and 20 contain higher percentages of differentially expressed genes (P |
| Databáze: | Directory of Open Access Journals |
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