| Autor: |
Tingting Sun, Zuwei Zhang, Liming Tian, Yu Zheng, Linxiang Wu, Yunyun Guo, Xiaohui Li, Yuanyuan Li, Hongwei Shen, Yingrong Lai, Junfeng Liu, Huanhuan Cui, Shasha He, Yufeng Ren, Guofen Yang |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Advanced Research, Vol 48, Iss , Pp 213-225 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2090-1232 |
| DOI: |
10.1016/j.jare.2022.08.014 |
| Popis: |
Introduction: Widespread intra-peritoneal metastases is a main feature of high grade serous ovarian carcinoma (HGSOC). Recently, the extent of tumour heterogeneity was used to evaluate the cancer genomes among multi-regions in HGSOC. However, there is no consensus on the effect of tumour heterogeneity on the evolution of the tumour metastasis process in HGSOC. Objectives: We performed whole-exome sequencing in multiple regions of matched primary and metastatic HGSOC specimens to reveal the genetic mechanisms of ovarian tumourigenesis and malignant progression. Methods: 63 samples (including ovarian carcinoma, omentum metastasis, and normal tissues) were used. We analyzed the genomic heterogeneity, traced the subclone dissemination and establishment history and compared the different genetic characters of cancer evolutionary models in HGSOC. Results: We found that HGSOC had substantial intra-tumour heterogeneity (median 54.2, range 0 ∼ 106.7), high inter-patient heterogeneity (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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